H2N2V1, Main, Exploration, bibRecord, 001E00

Interference between cold-adapted (ca) influenza A and B vaccine reassortants or between ca reassortants and wild-type strains in eggs and mice

Identifieur interne : 001E00 ( Main/Exploration ); précédent : 001D99; suivant : 001E01

Interference between cold-adapted (ca) influenza A and B vaccine reassortants or between ca reassortants and wild-type strains in eggs and mice

Auteurs : Julia R. Romanova ; Tatiana A. Ermachenko ; Galina I. Alexandrova ; Gregory A. Tannock [Australie]

Source :

Vaccine [ 0264-410X ] ; 1994.

RBID : ISTEX:7A70309D877CDB47D8E40C9DB4AF32CA056F81AE

English descriptors

Teeft :
- Allantoic fluid, Animals inoculated, Attenuated, Attenuated influenza, Chick embryos, Days post inoculation rgure, Different influenza, Different times, Dos, Dual infection, Eidso, Embryo, Equal doses, Equal volume, Gene composition, Hyperimmune serum, Individual mice, Infectious virus, Influenza, Influenza strain, Influenza viruses, Inoculated, Inoculation, Inoculum, Lung extracts, Mice inoculated, Mouse, Outbred mice, Parental viruses, Present study, Reassortant, Reassortant viruses, Reassortants, Recombinant, Replication, Respiratory tract, Serum titres, Simultaneous administration, Titre, Turbinate, Vaccine, Virus, Virus titres, Virus vaccines.

Abstract

Abstract: Interference between pairs of cold-adapted (ca) influenza A and B vaccine reassortant viruses and between ca influenza B reassortant viruses and wild-type influenza strain A/PR/8/34 was studied in embryonated eggs and/or in the respiratory tract of three strains of mice. Interference in eggs between ca A and B reassortants occurred after 2 days but was masked by later cycles of growth. When doses of 106 EID50 of the reassortant viruses B/60/32/R and A/47/6/R were administered to outbred mice, interference with the growth of A/47/6/R occurred in the turbinates; interference with the growth of B/60/32/R did not occur. However, interference with the growth of B/60/32/R was noted in the lungs of Balb/c mice after co-infection with 106 EID50 of both A/PR/8/34 and B/60/32/R. Interference did not occur when the dose of B/60/32/R was increased to 107 EID50 per mouse. When CBA mice were co-infected with 106 EID50 of both B/60/32/R and the influenza A ca reassortant R/34, or 106 EID50 of B/60/32/R,R/34 and A/Leningrad/134/57, interference did not occur. Interference could not be detected in mice following dual infection from serum responses to individual viruses.

Url:

https://api.istex.fr/ark:/67375/6H6-4LKJ9687-9/fulltext.pdf

DOI: 10.1016/0264-410X(94)90006-X

Affiliations:

Australie

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Interference between pairs of cold-adapted (ca) influenza A and B vaccine reassortant viruses and between ca influenza B reassortant viruses and wild-type influenza strain A/PR/8/34 was studied in embryonated eggs and/or in the respiratory tract of three strains of mice. Interference in eggs between ca A and B reassortants occurred after 2 days but was masked by later cycles of growth. When doses of 106 EID50 of the reassortant viruses B/60/32/R and A/47/6/R were administered to outbred mice, interference with the growth of A/47/6/R occurred in the turbinates; interference with the growth of B/60/32/R did not occur. However, interference with the growth of B/60/32/R was noted in the lungs of Balb/c mice after co-infection with 106 EID50 of both A/PR/8/34 and B/60/32/R. Interference did not occur when the dose of B/60/32/R was increased to 107 EID50 per mouse. When CBA mice were co-infected with 106 EID50 of both B/60/32/R and the influenza A ca reassortant R/34, or 106 EID50 of B/60/32/R,R/34 and A/Leningrad/134/57, interference did not occur. Interference could not be detected in mice following dual infection from serum responses to individual viruses.</div>
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Interference between cold-adapted (ca) influenza A and B vaccine reassortants or between ca reassortants and wild-type strains in eggs and mice

Interference between cold-adapted (ca) influenza A and B vaccine reassortants or between ca reassortants and wild-type strains in eggs and mice

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri